Research areas:

Research areas:

The major scientific trends  

• Development of the new methods for synthesis and modification of organic hydroxylamine derivatives (including nitroxides, nitrones, Alkoxyamines, etc.) and a search for the new fields of application of these compounds.
• Molecular design and synthesis of functional spin probes (i.e., those designed to monitor pH, thiols, nitric oxide NO, etc.) for investigation of various complex systems, including biological samples and models, living animals, sorbents, catalysts, etc..
• Molecular design and synthesis of specific spin labels for studies of structure and dynamics of molecular and supramolecular systems, including biological macromolecules and their complexes.
• Molecular design and synthesis of spin traps and spin probes for studies of processes involving short-living free radicals, including biogenic reactive oxygen species.
• The studies of antioxidant properties of nitroxides, hydroxylamines and nitrones; development of the therapeutic agents on the basis of the above mentioned compounds, for prevention and treatment of various pathologies, which origination and/or development is associated with reactive oxygen species; targeting of nitroxide-based antioxidants using natural and/or synthetic biologically active molecules residues.
• Development nitroxide and/or alkoxyamine mediators of free radical polymerization of vinyl monomers.
• Molecular design and synthesis of paramagnetic ligands, paramagnetic liquid crystals and similar nitroxide-containing compounds for preparations of new organic and metalocomplex magnetic materials.
• Development of nitroxide-based materials for microelectronic components, such as organic accumulators, dye-sensitized solar cells, data storage devices, etc..
• Molecular design and synthesis of new 1,1-diphosphonate-based calcium metabolism regulators and cytostatic drugs.

Scientific achievements

• The convenient scalable technologies have been developed for preparation of 1,2-hydroxyaminooxymes, 1,2-hydroxyaminoketones, N,N’-bis-hydroxyamines and similar building blocks from easily available chemicals; the utility of these blocks for synthesis of various heterocyclic systems have been demonstrated.
• As a result of extensive studies of reactivities of nitrone and imine moieties in various heterocyclic systems, the original general methods have been developed for chemical modification and synthesis of practically useful compounds.
• The original spin probes, the derivatives of stable nitroxides of imidazoline and imidazolidine series, have been developed, which EPR spectra are highly sensitive to pH changes. Based on these compounds, the methods have been developed for local pH monitoring in microvolumes of heterogeneous samples of various origin (in liposomes, polyelectrolyte pores, membrane surfaces, subcellular fractions and compartments, in extracellular media, in isolated organs and living tissues in vivo), for studies of proton transport, for studies of surface potentials of catalysts, sorbents, membranes, biomacromolecules, etc.The methods have been developed for preparation of imidazoline and/or pyrroline nitroxides with bulky substituents or spirocyclic moieties adjacent to nitroxide group; these nitroxides were shown to be resistant to reduction in biological samples.

Collaboration with:

• Pacific Institute of Bioorganic Chemistry Far-East Branch of Russian Academy of Science;
• Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus;
• Buryat State University;
• Institute of Problems of Chemical and Energetic Technologies Siberian Branch of RAS;
• JSC International research and Production holding “Phytochemistry” (Karaganda, Kazakhstan);
• Institute of Chemistry and Chemical Technology Mongolian Academy of Sciences;
• Institute of Organic Chemistry, University of Cologne (Kцln, Germany);
• Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, USA.

The major scientific trends of current researchs/Priority directions

• Basic. V.36. “Theoretical chemistry and methodology of oranic synthesis development; new methods of physic-chemical investigations”.
• Interdisciplinary Integration Projects
  • V.37: “Current problems of chemistry of materials, including nanomaterials”.
  • V.41:“Chemical problems of creation of pharmacologically active compounds of new generation”.

Current projects

• Headed or coordinated by laboratory researchers
  • RAS basic project V.36.6.8:
    • “Development of methods for synthesis of heteroatom-containing organic compounds for biomedical research and for preparation of new materials”. Headed by Prof. Igor A. Grigor’ev.
  • RFBR Projects No.:
    • 11-03-92107-ЯФ_а “Development of novel all-organic liquid crystalline nitroxide radical compounds showing strong magnetic interactions at high temperatures”. Head from RF – Grigor’ev I.A.
    • 12-03-00718-а “Development of specifically targeted nitroxides and hydroxylamines for red-ox status regulation”. Head – Prof. Grigor’ev I.A.
    • 12-03-00737-а “A new synthetic strategy for sterically hindered nitroxides based on intramolecular 1,3-dipolar cycloaddition in alkenyl nitrones”. Head – Dr. Kirilyuk I.A.
    • 12-03-31330 мол_а “Molecular design, synthesis and properties of new redox systems based on nitroxides”. Head – Mostovich E.A.
• Projects or programs in which the Laboratory is engaged
  • Federal research program RF “Physico-chemical studies of functional properties of new nitroxides and of nitroxide-based high-tech materials” headed by Prof Bagryanskaya (application 2012-1.2.1-12-000-1005-020).
  • Moscow city regional scientific programs:
    • “Development and practical application of new methods of healthcare, prophylaxis and diagnostics of cancer, infectious and another dangerous diseases”.
    • “Synthesis and studies of diphosphonic acids as a complexones for calcium metabolism regulation in atherosclerosis plaque”.
  • Interdisciplinary Integration Projects of SB RAS, V.37
    • Project No. 1 “Synthesis of functional nitroxides aimed to create new manetoactive compounds and materials” (Coordinated by corresponding member of RAS Ovcharenko V.I., ITC SB RAS).
    • Project No. 129 “A comprehensive study of soft media condition in electromagnetic field aimed to design highly efficient energy converters of new generation” (Coordinated by Dr Sci Klement’ev V.M., ILP SB RAS).
  • Interdisciplinary Integration Project of SB RAS, V.41
    • Project No. 52 “Oncogenesis of glioma and human brain reparation” (Coordinators: Dr Sci Mordvinov V.A. (ICG SB RAS) and corresponding member of RAS Krivoshapkin A.L. (ICG SB RAS).
  • RFBR Projects No.
    • 10-04-91331-ННИО_а “Nano-electrostatics of biological interfaces”. Head from RF– Academician Skulachev V.P. (MSU).
    • 12-03-01042-а “Novel synthetic methodologies for homo- and co-polymer nanostructured materials”. Head – Dr. Edeleva M.V., ITC SB RAS).
    • 12-04-01435-а “Development and application of new spin probes for in vivo EPR tomography and EPR spectroscopy of spin-labeled proteins”. Head – Bagryanskaya E. G. (NIOCh SB RAS).
   

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PUBLICATIONS

Publications over the past years