В журналt Archiv der Pharmazie, (IF 5,1) опубликована статья с участием сотрудников Института - к.х.н. А.С. Соколовой(снс, ЛФАВ), д.х.н. О.И. Яровой (внс, ЛФАВ), к.б.н. Д.С. Баева (снс, ЛФИ), д.б.н., проф. Т.Г. Толстиковой (завлаб ЛФИ) и и чл.корр. РАН, д.х.н., проф. Н.Ф. Салахутдинова (зав. отделом ОМХ):
Design, synthesis and antiviral evaluation of novel conjugates of the 1,7,7-trimethylbicyclo[2.2.1]heptane scaffold and saturated N-heterocycles via 1,2,3-triazole linker
Anastasiya S. Sokolova, Olga I. Yarovaya, Oleg I. Artyushin, Elena V. Sharova, Dmitriy S. Baev, Ekaterina D. Mordvinova, Dmitriy N. Shcherbakov, Tatiana A. Shnaider, Tatiana V. Nikitina, Iana L. Esaulkova, Polina A. Ilyina, Vladimir V. Zarubaev, Valery K. Brel, Tatyana G. Tolstikova, Nariman F. Salakhutdinov
Archiv der Pharmazie,
Volume 357, Issue 3, March 2024, 2300549
doi: 10.1002/ardp.202300549
Abstract
A new series of heterocyclic derivatives with a 1,7,7-trimethylbicyclo[2.2.1]heptane fragment was designed, synthesised and biologically evaluated. Synthesis of the target compounds was performed using the Cu(I) catalysed cycloaddition reaction. The key starting substances in the click reaction were an alkyne containing a 1,7,7-trimethylbicyclo[2.2.1]heptane fragment and a series of azides with saturated nitrogen-containing heterocycles. Some of the derivatives were found to exhibit strong antiviral activity against Marburg and Ebola pseudotype viruses. Lysosomal trapping assays revealed the derivatives to possess lysosomotropic properties. The molecular modelling study demonstrated the binding affinity between the compounds investigated and the possible active site to be mainly due to hydrophobic interactions. Thus, combining a natural hydrophobic structural fragment and a lysosome-targetable heterocycle may be an effective strategy for designing antiviral agents.
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