Laboratory of Directed Transformations of Natural Compounds (LDTNC)

Resercher ares

The main activities of the laboratory are:

• Search and creation of new highly effective, low-toxic domestic drugs for the treatment and prevention of socially significant diseases. The basis of the creation of medicinal agents are such approaches as:
  1. Directed modification of natural compounds (alkaloids, terpenoids, coumarins, flavonoids, etc.)
  2. Analysis and modification of structures of known natural biologically active compounds;
• Creation of highly efficient and safe drug delivery systems based on natural compounds and their derivatives;
• Development of new regioselective and stereoselective approaches and synthesis methods for the modification of natural compounds for the production of target substances;
• Improving the structure of leading compounds in order to increase their pharmacodynamic and pharmacokinetic characteristics, as well as activity and selectivity, using for this purpose techniques such as the synthesis of structural analogs based on the principle of three-dimensional pharmacophore similarity, changing the conformational mobility of the original molecule, bioisteric replacement, changing the balance of lipophilic and hydrophilic groups, creating peptidomimetics, changing metabolizable groups, etc.

Partners of the laboratory:

• Novosibirsk State University;
   
• Moscow State University;
  
  
• School of Chemistry, University of Auckland (New Zealand);
   
• Institute of Chemical Biology and Fundamental Medicine;
   
• Institute of Catalysis;
   
• Abo University (Finland);
   
• St. Petersburg Pasteur Research Institute of Epidemiology and Microbiology;
   
• State Research Center of Virology and Biotechnology VECTOR.
   

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